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All POCT Products
apo6884 Grünschnabel Posts: 10	# 21.03.2023 - 05:44:29     zitieren All POCT Products Alpha Fetoprotein (AFP) Test Kit (Fluorescence Immunoassay) Application It is suitable for quantitative determination of alpha-fetoprotein (AFP) in human plasma or whole blood in vitro. Package 1 test/kit, 5 tests/kit, 10 tests/kit, 25 tests/kit, 50 tests/kit. Glossary Alpha-fetoprotein (AFP) is a glycoprotein, which belongs to the albumin family and is mainly synthesized by fetal liver cells and yolk sac. Alpha-fetoprotein has a high concentration in fetal blood circulation, and it decreases after birth. It is basically replaced by albumin in 2 to 3 months after birth, and it is difficult to detect in blood, so the content in adult serum is extremely low. . Alpha-fetoprotein has many important physiological functions, including transport function, bidirectional regulatory function as a growth regulator, immunosuppression, induction of apoptosis of T lymphocytes and so on. Alpha-fetoprotein is closely related to the occurrence and development of liver cancer and various tumors. It can show high concentration in various tumors and can be used as a positive detection index for various tumors. At present, it is mainly used as a serum marker of primary liver cancer in clinic for the diagnosis and curative effect monitoring of primary liver cancer. Clinical Significance 1. Detection of serum AFP levels in childhood: liver cancer, hepatoblastoma, gonadal teratoblastoma, hepatitis and other AFP levels increased. 2. Detection of serum AFP content in adults: 60% to 70% of patients with primary liver cancer have increased AFP levels, and testicular cancer, ovarian tumors, malignant teratoma, pancreatic cancer, gastric cancer, bowel cancer, lung cancer and other patients also have increased AFP levels. 3. Serum AFP levels in patients with benign liver diseases such as acute and chronic hepatitis and liver cirrhosis are increased to varying degrees, but most of them are lower than 1000ug/L, and the increase is related to the degree of necrosis and regeneration of liver cells. 4. Generally, the increase of AFP content in benign liver disease is transient and usually lasts for 2-3 weeks. Malignant tumors continued to increase. Therefore, dynamic observation of serum AFP levels can not only differentiate benign and malignant liver diseases, but also diagnose liver cancer early. 5. Under physiological conditions, alpha-fetoprotein is secreted by newborn naive hepatocytes. The fetal hepatocytes are not fully developed (differentiated), and the amount of alpha-fetoprotein secreted is large, which can enter the maternal blood through the umbilical cord blood, so pregnant women during pregnancy. alpha-fetoprotein will be positive. Components The kit is composed of alpha-fetoprotein detection reagent card, detection buffer, ID card, instruction manual, etc. Alpha-fetoprotein detection reagent card: alpha-fetoprotein monoclonal antibody (0.1-2 mg/mL), anti-chicken IgY polyclonal antibody (0.1-2 mg/mL), time-resolved fluorescent microsphere-labeled alpha-fetoprotein monoclonal antibody (0.1 ~ 2 mg/mL) and time-resolved fluorescent microsphere-labeled chicken IgY antibody (0.1 ~ 2 mg/mL). Detection buffer: 0.01M phosphate buffer, pH=7.4卤0.5, Proclin 300 0.3g/L. Alpha-fetoprotein (AFP) Alpha-fetoprotein (AFP) is a glycoprotein mainly synthesized in fetal liver. At the 13th week of fetus, AFP accounts for 1/3 of the total plasma protein, reaching the peak at 30 weeks of gestation, and then gradually decreasing. level (less than 30渭g/L). AFP can enter the maternal blood circulation through the amniotic fluid part. In maternal amniotic fluid or maternal plasma, AFP can be used for fetal prenatal monitoring. Such as in neural tube defects, spina bifida, anencephaly, etc., AFP can enter the amniotic fluid through the open neural tube, resulting in a significant increase in its content in the amniotic fluid. Fetal death in the uterine cavity, teratoma and other birth defects can also have increased AFP in amniotic fluid. In adults, AFP can be elevated in the serum of about 80% of patients with liver cancer, and the positive rate of AFP in germ cell tumors is 50%. When liver cells become cancerous, the function of producing this protein is restored, and as the disease deteriorates, the content in serum will increase sharply, and alpha-fetoprotein has become a specific clinical indicator for the diagnosis of primary liver cancer. In 2020, the Chinese Society of Clinical Oncology (CSCO) guidelines for the diagnosis and treatment of liver cancer recommend that the criteria for the diagnosis of liver cancer with elevated alpha-fetoprotein are: 1. AFP鈮?00ng/ml; 2. Exclude chronic or active hepatitis, liver cirrhosis, testicular or ovarian embryo-derived tumors and pregnancy, etc., and liver cancer is highly suspected. 3. It is worth noting that about 30% of liver cancer patients have normal AFP levels, and alpha-fetoprotein alloplasm and abnormal prothrombin should be detected when diagnosing liver cancer. In addition, active hepatitis, some reproductive system tumors, gastrointestinal tumors, pregnancy, etc. may also cause increased alpha-fetoprotein. Alpha-fetoprotein (AFP) is a glycoprotein that belongs to the albumin family and is mainly synthesized by fetal liver cells and yolk sac. Alpha-fetoprotein has a high concentration in fetal blood circulation, and it decreases after birth. It is basically replaced by albumin in 2 to 3 months after birth, and it is difficult to detect in blood, so the content in adult serum is extremely low. . Alpha-fetoprotein has many important physiological functions, including transport function, bidirectional regulatory function as a growth regulator, immunosuppression, induction of apoptosis of T lymphocytes and so on. Alpha-fetoprotein is closely related to the occurrence and development of liver cancer and various tumors. It can show high concentration in various tumors and can be used as a positive detection index for various tumors. At present, it is mainly used as a serum marker of primary liver cancer in clinic for the diagnosis and curative effect monitoring of primary liver cancer. FAQ Q: When can I get the price? A: Usually we quote within 8 hours after we get your inquiry. Q: What鈥檚 your MOQ? A: If we have the products in stock, it will be no MOQ. If we need to produce, we can discuss the MOQ according to customer鈥檚 exact situation. Q: How long is your delivery time? A: The general delivery time is 10-15 days after receiving your order confirmation. Anther, if we have the goods in stock, it will only take 1-2 days. Q: Do you provide sample ? Is it free? A: If the sample is low value, we will provide the free sample with freight collect. But for some high value samples, we need to collect the sample charge.All POCT Products website:modaivds.com/all-poct-products/

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